50

Acute oral LD₅₀ for mice >5000, rats >4000 mg/kg.

Acute percutaneous LD₅₀ for rats >1000, rabbits >4000 mg/kg. Mild eye irritant; non-irritating to skin (rabbits). No skin sensitisation (guinea pigs).

LC₅₀ (4 h) for rats >2.3 mg/l air.

(90 d) for rats 200 mg/kg diet; (1 y) for dogs 100 mg/kg diet. No significant effects observed in a 2 y carcinogenicity study in mice and a 3-generation reproduction study in rats.

WHO (a.i.) U; EPA (formulation) III

Acute oral LD₅₀ for Japanese quail >3160 mg/kg. Dietary LC₅₀ (8 d) for bobwhite quail and mallard ducks >5000 mg/kg diet.

LC₅₀ (96 h) for rainbow trout >19, bluegill sunfish >32 mg/l.

LC₅₀ (48 h) >10 mg/l.

LC₅₀ (14 d) for earthworms >1400 mg/kg.

Only small amounts of residue (normally <0.1 mg/kg) are likely in cottonseed.

In rats and goats, metabolism involves hydroxylation of the phenyl group, followed by formation of water-soluble conjugates. Following oral administration, the compound is excreted in the urine and faeces within 96 hours.

Strongly adsorbed by soil. DT₅₀ in soil c. 26-144 d (aerobic), 28 d (anaerobic). Essential soil microbial processes are only temporarily influenced, if at all.

Product analysis by hplc. Residues determined by hplc or by glc with ECD of a derivative.